Adding a certain compound to certain chemical reactions, such as: 4415-73-0, 1,1-Cyclobutanedimethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 4415-73-0, blongs to alcohols-buliding-blocks compound. COA of Formula: C6H12O2
To a solution of cyclobutane-l,l-diyldimethanol (10.00 g, 86.1 mmol) in N,N- dimethylformamide (200 mL), imidazole (8.8 g, 129.1 mmol) and tert-butyldimethylsilyl chloride (12.98 g, 86.1 mmol) were added in one portion at 0 C. The reaction mixture was stirred at 0 C for 10 minutes and then warmed to room temperature for 4 hours. The reaction mixture was quenched with water (500 mL) and extracted with ethyl acetate (250 mL x 3). The combined organic layer was washed with water, brine, dried over MgS04 and concentrated. The resultant residue was purified by flash chromatography (120 g silica gel, 0- 20 % ethyl acetate in hexanes) to get the title compound as a colorless oil. NMR (300 MHz, CDCb): delta 3.71 (s, 1H), 3.69 (d, J= 5.0 Hz, 1H), 2.87 (t, J= 5.4 Hz, 1H), 2.00-1.72 (m, 6H), 0.91 (s, 6H), 0.10 (s, 6H).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,4415-73-0, its application will become more common.
Reference:
Patent; FGH BIOTECH, INC.; UESUGI, Motonari; KINCAID, John; HUFF, Joel; (150 pag.)WO2018/49080; (2018); A1;,
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