Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 52273-77-5, name is 2-(3-Aminophenyl)ethanol. A new synthetic method of this compound is introduced below., SDS of cas: 52273-77-5
Step 4 Preparation of 3-{2-[6-(4-fluoro-phenyl)-pyridin-2-ylmethoxy]-ethyl}-phenyl amine Using a similar procedure to step 1 of Example 1 222 mg (1 mmol) of the product of step 3 above was reacted with 137 mg (1 mmol) of 3-(2-hydroxy ethyl) phenyl amine. After purification on silica with 40% ethyl acetate:hexane elution, recovered 0.21 g (65%) of an oil. NMR (200 MHz,CDCl3) delta8.11 (m, 2H, ArH), 7.79 (m, 2H, ArH), 7.18-7.38 (m, 6H,ArH), 7.08 (d,J=8 hz,1H,ArH),4.63 (s, 2H, OCH2),4.53(bs,2H,NH2), 3.78 (t, J=7 Hz, 2H, OCH2), 2.92 (t, J=7 Hz,2H,ArCH2)
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Reference:
Patent; Wyeth; US2003/203941; (2003); A1;,
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