Reference of 4254-29-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 4254-29-9, name is 2,3-Dihydro-1H-inden-2-ol, molecular formula is C9H10O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Example 94 yV7,/V7-Dimethyl-7,8-dihydro-6W-indeno[5,6-e][1,2,4]triazine-3,7-diamine 1 -Oxide (111). /V,/V-Dimethyl-2-indanamine (107). Methanesulfonyl chloride (11.5 mL, 149 mmol) was added dropwise to a stirred solution of 2-indanol (106) (20 g, 149 mmol) and JPr2NEt (28.6 mL, 164 mmol) in DCM (300 mL) at 0 0C, and the solution stirred at 20 0C for 16 h. The solution was washed with 1 M HCI (80 mL), aqueous saturated NaHCO3 solution (80 mL) and brine (100 mL), dried and the solvent evaporated. The residue was recrystallised from EtOH to give 2,3-dihydro-1/V-inden-2-yl methanesulfonate (31.14 g, 98%) as a white solid. Aqueous HNMe2 (40%, 180 mL, 1.42 mol) was added slowly to a stirred solution of mesylate (30.25 g, 143 mmol) in DMF (200 mL) and the solution stirred at 20 0C for 16 h. The solution was partitioned between EtOAc (400 mL) and water (800 mL) and the organic fraction washed with water (3 x 80 mL), brine (100 mL), dried and the solvent evaporated. The residue was suspended in 1 M HCI (400 mL) and washed with DCM (3 x 80 mL). The pH of the aqueous fraction was adjusted to 14 with NaOH, the mixture chilled at 5 0C for 8 h and the precipitate filtered. The precipitate was washed with water (50 mL) and dried to give amine 107 (21.54 g, 93%) as a light gray solid: 1H NMR delta 7.10-7.17 (m, 4 H, Harom), 3.01-3.08 (m, 3 H, H-2, CH2), 2.82-2.91 (m, 2 H1 CH2), 2.31 [s, 6 H, N(CHa)2].
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 4254-29-9, 2,3-Dihydro-1H-inden-2-ol.
Reference:
Patent; AUCKLAND UNISERVICES LIMITED; WO2006/104406; (2006); A1;,
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