Application of 612-16-8 , The common heterocyclic compound, 612-16-8, name is (2-Methoxyphenyl)methanol, molecular formula is C8H10O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
General procedure: Reactions were performed in a magnetically stirred round bottomed flask fitted with acondenser and placed in a temperature controlled oil bath. 1,2-Diamine (2 mmol)was added to alcohol (3 mmol) and the reaction mixture was allowed to stir at 135C in an open (air) atmosphere. After disappearance of the diamine (reaction was monitored by TLC)or after the appropriate time, the reaction mixture was cooled to roomtemperature. The crude residue was further purified by column chromatography using silica gel (100-200 mesh) to afford pure products. All the products wereidentified on the basis of NMR and mass spectral data
The synthetic route of 612-16-8 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Marri, Mahender Reddy; Peraka, Swamy; Macharla, Arun Kumar; Mameda, Naresh; Kodumuri, Srujana; Nama, Narender; Tetrahedron Letters; vol. 55; 48; (2014); p. 6520 – 6525;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts