7 Sep 2021 News New downstream synthetic route of 623-04-1

According to the analysis of related databases, 623-04-1, the application of this compound in the production field has become more and more popular.

Related Products of 623-04-1, Adding some certain compound to certain chemical reactions, such as: 623-04-1, name is (4-Aminophenyl)methanol,molecular formula is C7H9NO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 623-04-1.

General procedure: To a solution of particular aromatic amine in 1,4-Dioxane (at the rate of 50 mg/ml) at -15.0 C, 5 equivalents of 2 M Sulphuric acid was added in small instalments while stirring. After 5 min 2 equivalents of 3 M sodium nitrite was added drop wise and after 30 min 3 equivalents of 3 M sodium azide was added drop wise carefully. Reaction was brought to room temperature and extracted with diethyl ether for at least three times. Organic layers were washed with saturated sodium bicarbonate solution two times, dried over anhydrous sodium sulphate and concentrated to a minimum volume under reduced pressure on Rotary evaporator without making use of heating from water bath.

According to the analysis of related databases, 623-04-1, the application of this compound in the production field has become more and more popular.

Reference:
Article; Farooq, Saleem; Shakeel-U-Rehman; Hussain, Aashiq; Hamid, Abid; Qurishi, Mushtaq A.; Koul, Surrinder; European Journal of Medicinal Chemistry; vol. 84; C; (2014); p. 545 – 554;,
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