Application of 4541-14-4 , The common heterocyclic compound, 4541-14-4, name is 4-(Benzyloxy)butan-1-ol, molecular formula is C11H16O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
DMSO (9.8 mL, 138.8 mmol) was added at -78 C to a solution of oxalyl chloride (9.7 mL, 111.0 mmol) in CH2Cl2 (100 mL), and the resulting solution was stirred for 15 min. A solution of the mono benzylated alcohol 18 (10 g, 55.5 mmol) in CH2Cl2(50 mL), was added drop wise at -78 C over 30 min. After the solution had been stirred for an additional 30 min, Et3N (38.2 mL, 275.0 mmol) was added and the reaction mixture was allowed to warm to room temperature and stirred for 1 h. The reaction mixture was poured into ice cooled water and extracted with CH2Cl2. The organic layer was washed with brine, dried with Na2SO4 and concentrated under reduced pressure to give crude aldehyde (8.9 g) which was directly used for next step without further purification.
The synthetic route of 4541-14-4 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Avuluri, Srilatha; Bujaranipalli, Sheshurao; Das, Saibal; Yadav; Tetrahedron Letters; vol. 59; 39; (2018); p. 3547 – 3549;,
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