Synthetic Route of 870-72-4 ,Some common heterocyclic compound, 870-72-4, molecular formula is CH3NaO4S, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
EXAMPLE 16 200 g of 2-(3-carbamoylphenylamino)-N-(3,4-dimethoxyphenethyl)acetamide trihydrate and 65.2 g of sodium hydroxymethanesulfonate were suspended in 400 ml of water, and the suspension was refluxed over night. After cooling, the reaction mixture was washed with chloroform, and an insoluble material was removed by filtration. The filtrate was concentrated in vacuo. The residue was dissolved in a mixture of 500 ml of water and 500 ml of ethanol under heating, and then the solution was cooled. The precipitate formed was collected by filtration and recrystallized from a mixture of water and ethanol to give 59.2 g of sodium N-(3-carbamoylphenyl)-N-(2-((2-(3,4-dimethoxyphenyl)ethyl)amino)-2-oxoethyl)aminomethanesulfonate dihydrate as colorless crystals with m.p. 253 to 255 C. (decomposition). Analysis for C20 H24 N3 O7 SNa.2H2 O: Calcd: C 47.15, H 5.54, N 8.25. Found: C 47.11, H 5.39, N 8.34. NMR (DMSO-d6): delta: 2.57 (2H, t, 6 Hz), 3.4-3.1 (2H, br), 3.67 (6H, s), 4.05 (2H, br), 4.29 (2H, br), 6.47-7.33 (8H, m), 7.75 (1H, br), 8.26 (1H, br).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 870-72-4, Hydroxymethanesulfonic Acid Sodium Salt, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Daiichi Pharmaceutical Co., Ltd.; US4985595; (1991); A;,
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