Application of 929-06-6 ,Some common heterocyclic compound, 929-06-6, molecular formula is C4H11NO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
Add a magnet to a 1L round bottom flask.Add (9.542 ml, 95.1113 mmol),Dichloromethane 150ml dissolved,Triethylamine (26.5133 ml, 190.2226 mmol) was added,Boc anhydride was added under stirring (24.9096 g,114.1335mmol). After the reaction was completed, the reaction solution was transferred to a rotary evaporator and concentrated. Methanol was added to dissolve the mixture. Under stirring, sodium bicarbonate powder (13 g) was added to neutralize triethylamine, suction filtered, and silica gel powder was added as a solid solution. Dry method,Column chromatography eluting with a gradient of 10% ethyl acetate/petroleum ether to 50% ethyl acetate/petroleum ether, gradient elution with 3% methanol/ethyl acetate to 6% methanol/ethyl acetate.The product was collected and evaporated to give 16.3341 g of compound in a yield of 83.77%.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 929-06-6, 2-(2-Aminoethoxy)ethanol, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Chongqing A Pugelei Biological Technology Co., Ltd.; Li Gaoquan; Chen Maofen; Wang Bin; Li Dajun; Zhang Qian; Shui Juyuan; Peng Liangyan; Huang Lei; He Tingting; Zhang Cuifang; Wu Xiaodan; Li Jianhuan; (39 pag.)CN107670050; (2018); A;,
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