Electric Literature of 637031-88-0, Adding some certain compound to certain chemical reactions, such as: 637031-88-0, name is 3,3-Difluorocyclobutanol,molecular formula is C4H6F2O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 637031-88-0.
To a mixture of A-84 (40 mg, 0.14 mmol), 3,3-difluorocyclobutanol (18.52 mg, 0.17 mmol) and Ph3P (74.89 mg, 0.29 mmol) in THF (2 mL) was added DIAD (57.73 mg, 0.29 mmol) under N2 at 60 C. The mixture was stirred at 60 C for 16 hours. After cooling to room temperature, the mixture was concentrated to the crude product that was purified by prep-TLC (silica gel, DCM) and prep-HPLC (Phenomenex Gemini (250 mm x 50 mm, 10 _) A = H20 (0.05% NH4OH) and B = CH3CN; 58-68 %B over 8 minutes) to afford Compound 59 (7.80 mg, 20.8 mmol) as a solid. H NMR (400MHz, CDC13) _ = 8.26 (d, 1H), 8.01 (d, 2H), 7.74 (d, 1H), 6.99 (d, 2H), 4.81-4.70 (m, 1H), 3.23-3.10 (m, 2H), 2.90-2.75 (m, 2H). LCMS R, = 1.29 min using Method A, MS ESI calcd. for Ci6H12F5N40 [M+H]+ 371.1, found 371.0.
According to the analysis of related databases, 637031-88-0, the application of this compound in the production field has become more and more popular.
Reference:
Patent; PRAXIS PRECISION MEDICINES, INC.; REDDY, Kiran; MARTINEZ BOTELLA, Gabriel; GRIFFIN, Andrew, Mark; MARRON, Brian, Edward; (364 pag.)WO2018/98499; (2018); A1;,
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