Application of 68327-04-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 68327-04-8, name is (1S,2S)-2-Aminocyclopentanol hydrochloride, molecular formula is C5H12ClNO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Example 119Synthesis of (1S,2S)-2-(3-flupsilonorophenethylamino)cyclopentanol (XIII-I) trans-(1S, 2S)-2-Aminocyclopentanol hydrochloride (1.51 g, 0.011 mol) and triethylamine (Et3N, 1.32 g, 1.81 g, 0.013 mol), 3 A molecular sieves (3 g) were dissolved in dry DCE (30 mL). The mixture was stirred at room temperature under a N2 atmosphere for 10 min. NaBH(OAc)3 (2.76 g, 0.013 mol) and 1-4 (1.38 g, 0.01 mol) was then added, and the reaction mixture was stirred at room temperature under a N2 atmosphere overnight. NaOH (1 M, 20 mL) was then added, and the organic layer was separated. The aqueous layer was extracted with CH2Cl2 (20 mL x 2). The combined organic layers were washed with 1 M NaOH (20 mL) and H2O (20 mL), and then dried over Na2SO4. The solvent was concentrated in vacuo. The residue was purified by column chromatography (silica gel, CH2Cl2 : MeOH = 9.5 : 0.5) to afford a pale-yellow oil (1.38 g, 62%)
According to the analysis of related databases, 68327-04-8, the application of this compound in the production field has become more and more popular.
Reference:
Patent; NORTHWESTERN UNIVERSITY; SILVERMAN, Richard, B.; JI, Haitao; LAWTON, Graham, R.; WO2008/42353; (2008); A1;,
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