As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 13807-89-1, name is 2-((4-Methoxybenzyl)oxy)ethanol, molecular formula is C10H14O3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Safety of 2-((4-Methoxybenzyl)oxy)ethanol
Dissolve 3.7ml of oxalyl chloride in dichloromethane (75ml) and control the temperature to -70 C.Dissolve dimethyl sulfoxide (6.4 ml) in dichloromethane (10 ml) and slowly dropwise.After completion of the dropwise addition, the reaction was performed for 1 hour.6 g (33.0 mmol) of 2- (4-methoxybenzyloxy) ethanol was dissolved in dichloromethane (5 ml) and slowly added. After two hours of reaction, triethylamine (12.5 ml) was slowly added dropwise.After 30 minutes of reaction, the temperature reduction device was removed and the temperature was raised to zero degrees.3N HCl was added slowly, extracted, and the organic layers were combined. With 1N HCl,Saturated sodium bicarbonate solution, washed with saturated brine, dried,The organic solvent was spin-dried to obtain 5 g of product.
With the rapid development of chemical substances, we look forward to future research findings about 13807-89-1.
Reference:
Patent; Nanjing Gurui Biological Technology Co., Ltd.; Mei Yan; (56 pag.)CN110734456; (2020); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts