Synthetic Route of 10160-28-8, Adding some certain compound to certain chemical reactions, such as: 10160-28-8, name is Non-8-yn-1-ol,molecular formula is C9H16O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 10160-28-8.
General procedure: 300 mg (1 eq, 1.42 mmol) of 7 was suspended in 11 mL of freshly distilled THF under argon. 745 mg (2 eq, 2.84 mmol) of triphenylphosphine was then added, followed by 198 muL (1.5 eq, 2.13 mmol) of 4-pentyn-1-ol. The flask was then placed in an ice bath and stirred for 10 min. 391 muL (1.4 eq, 1.99 mmol) of diisopropylazodicarboxylate (DIAD) was then added drop-wise. The reaction was stirred, allowing it to return to room temperature, for 72 h at which point the reaction appeared done by TLC (EtOAc,KMnO4 stain). The solvent was removed under reduced pressure, giving a viscous oil that was then subjected to high vacuum for 1 h before being dissolved in the minimum amount of ethyl acetate. After purification by flash chromatography (50% EtOAc in hexanes), 350 mg (89% yield) of the product was obtained as a white powder.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 10160-28-8, Non-8-yn-1-ol, other downstream synthetic routes, hurry up and to see.
Reference:
Article; McBrayer, Dominic; Kerwin, Sean M.; Molecules; vol. 20; 9; (2015); p. 16446 – 16465;,
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