Reference of 55414-72-7, Adding some certain compound to certain chemical reactions, such as: 55414-72-7, name is (2-Amino-5-methoxyphenyl)methanol,molecular formula is C8H11NO2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 55414-72-7.
The product of preparation 3 (300mg, 2.0mmol) in tetrahydrofuran (3mL) was added dropwise to a suspension of sodium hydride (60% dispersion in mineral oil, 54mg, 2.3mmol) in tetrahydrofuran (2mL). The mixture was stirred for 45 minutes and the temperature was maintained at -10C. The product of preparation 5 (357mg, 1.3mmol) in tetrahydrofuran (3mL) was added dropwise and the mixture was stirred for a further hour. The temperature was then allowed to increase to 25C and the reaction was quenched with sodium hydrogen carbonate solution (5mL), and diluted with ethyl acetate (20mL) and water (10mL). The organic phase was separated, washed with brine (10mL), dried over magnesium sulfate and concentrated in vacuo to give an oily residue. Purification of the oil by column chromatography on silica gel, eluting with dichloromethane: methanol, 100: 0 to 97: 3, afforded the title compound in 59% yield, 300mg. MS APCI+ m/z 390,392 [MH]+
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 55414-72-7, (2-Amino-5-methoxyphenyl)methanol, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; PFIZER LIMITED; PFIZER INC.; WO2005/121152; (2005); A1;,
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