Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 19064-18-7, name is (2,6-Difluorophenyl)methanol. This compound has unique chemical properties. The synthetic route is as follows. Computed Properties of C7H6F2O
A previously cooled to 0 C solution of 3.5 g (27.53 mmol) 2-fluoro-4-methoxy (CAS: 175965-83-0) and 3.97 g (27.53 mmol) of 2,6-difluorobenzyl alcohol in 97 ml of dry tetrahydrofuran was added dropwise with 27.5 ml (27.53 mmol) of a IM solution of potassium tert-butoxide in tetrahydrofuran.The obtained mixture was stirred for 18 hours at room temperature.The solvent was evaporated and the residue was partitioned between water and ethyl acetate.The organic phase was separated, washed with water and aqueous sodium chloride solution, dried over sodium sulfate, filtered and evaporated in vacuo to give 5.77 g (yield 66%, purity 79%) of the product.
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Reference:
Patent; BAYER PHARMA AKTIENGESELLSCHAF; VAKALOPOULOS, Alexandros; FOLLMANN, Markus; BUCHGRABER, Philipp; HARTUNG, Ingo; LINDNER, Niels; WUNDER, Frank; STASCH, Johannes-Peter; MARQUARDT, TOBIAS; REDLICH, Gorden; DIETZ, Lisa; LI, Volkhart Min-Jian; (391 pag.)TW2016/5850; (2016); A;,
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