Related Products of 140373-17-7, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 140373-17-7 as follows.
To a solution of 6-(naphthalen-2-yl)-4-oxo-4,5-dihydropyrazolo[1,5-a]pyrazine-2-carboxylic acid (Intermediate 3A, 100 mg, 328 pmol) and N,N-diisopropylethylamine (170 pi, 980 pmol) in DMF (5.0 ml) were added 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (69.1 mg, 360 pmol) and 1-hydroxy-7-azabenzotriazole (22.3 mg, 164 pmol). The mixture was stirred at RT for 1H. Then, 2-amino-2-(4-fluorophenyl)ethanol (50.8 mg, 328 pmol) was added, and stirring was continued overnight at RT, followed by heating to 50C for 5 h. After cooling to RT, the mixture was poured into water, and the precipitate was collected by filtration, washed with water and dried to afford the title compound. Yield: 66.1 mg (44% of theory). LC/MS [Method 7]: Rt = 0.90 min; MS (ESIpos): m/z = 443 [M+H]+. 1H-NMR (400 MHz, DMSO-d6): d [ppm] = 11.88 (br. s, 1H), 8.64 (d, 1H), 8.39 (s, 1H), 8.23 (s, 1H), 8.04 (d, 1H), 8.01-7.96 (m, 2H), 7.89 (dd, 1H), 7.64-7.57 (m, 2H), 7.48-7.39 (m, 3H), 7.20-7.12 (m, 2H), 5.11-5.01 (m, 2H), 3.79-3.67 (m, 2H).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,140373-17-7, its application will become more common.
Reference:
Patent; BAYER AKTIENGESELLSCHAFT; BAYER PHARMA AKTIENGESELLSCHAFT; MUeLLER, Steffen; SCHOHE-LOOP, Rudolf; ORTEGA, HERNANDEZ, Nuria; SUeSSMEIER, Frank; JIMENEZ NUNEZ, Eloisa; BRUMBY, Thomas; LINDNER, Niels; GERDES, Christoph; POOK, Elisabeth; BUCHMUeLLER, Anja; GAUGAZ, Fabienne, Zdenka; LANG, Dieter; ZIMMERMANN, Stefanie; EHRMANN, Alexander, Helmut, Michael; GERISCH, Michael; LEHMANN, Lutz; TIMMERMANN, Andreas; SCHAeFER, Martina; SCHMIDT, Georg; SCHLEMMER, Karl-Heinz; FOLLMANN, Markus; KERSTEN, Elisabeth; WANG, Vivian; GAO, Xiang; WANG, Yafeng; (801 pag.)WO2019/219517; (2019); A1;,
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