Synthetic Route of 6966-10-5, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 6966-10-5, name is (3,4-Dimethylphenyl)methanol. A new synthetic method of this compound is introduced below.
General procedure: General procedure for the synthesis of phenanthridines 3: To a 25 mL tube containing a magnetic stir bar, was added 2-isocyanobiphenl 1 (0.2mmol, 1.0 equiv), Fe(acac)2 (20% mmol, 25.4mg), 4 AMS (100mg), TBHP (5.5M in nonane, 0.15ml, 0.8mmol, 4.0 equiv), benzyl alcohol 2 (0.8mmol, 4.0 equiv), and MeCN (2ml). The resulting mixture was heated under O2 at 100C for 24h. The solvent was removed under vacuum, and the residue was purified by column chromatography (SiO2, petroleum ether/ethyl acetate=1:10) to provide the desired products 3.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,6966-10-5, (3,4-Dimethylphenyl)methanol, and friends who are interested can also refer to it.
Reference:
Article; Nie, Ziyi; Ding, Qiuping; Peng, Yiyuan; Tetrahedron; vol. 72; 50; (2016); p. 8350 – 8357;,
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