With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.15484-46-5, name is Methyl 2-(hydroxymethyl)acrylate, molecular formula is C5H8O3, molecular weight is 116.12, as common compound, the synthetic route is as follows.category: alcohols-buliding-blocks
General procedure: Under N2 atmosphere and at 0 C, to a stirred solution of MBHalcohols 1 (0.3 mmol) and PPh3 (0.6 mmol) in EtOAc orCH2Cl2 (2 mL) in a Schlenk tube (25 mL) was slowly addedazodicarboxylates 2 (0.6 mmol) over 5 minutes by the means ofa microsyringe. The resulting reaction mixture was allowed towarm up to room temperature and stirred until the MBH alcohols1 were completely consumed, as monitored by TLC. Thesolvent was removed under reduced pressure and the residuewas purified by column chromatography on silica gel (gradienteluant: petroleum ether/ethyl acetate 9:1-3:1) to afford thehydrazines 3.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,15484-46-5, Methyl 2-(hydroxymethyl)acrylate, and friends who are interested can also refer to it.
Reference:
Article; Xu, Silong; Shang, Jian; Zhang, Junjie; Tang, Yuhai; Beilstein Journal of Organic Chemistry; vol. 10; (2014); p. 990 – 995;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts