Electric Literature of 13330-96-6, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.13330-96-6, name is 4-(Dimethylamino)butan-1-ol, molecular formula is C6H15NO, molecular weight is 117.19, as common compound, the synthetic route is as follows.
To a solution of 4-nitrophenyl(6Z,9Z,26Z,29Z)-pentatriaconta-6,9,26,29-tetraen-18-yl carbonate (0.12 g, 0.18 mmol) obtained in Reference Example 5, 4-dimethylamino-1-butanol (0.22 g, 1.8 mmol), and diisopropylethylamine (0.10 g, 0.72 mmol) in dichloromethane (10 mL), 4-dimethylaminopyridine (0.09 g, 0.72 mmol) was added, and the mixture was reacted overnight at room temperature. After water treatment, the reaction mixture was subjected to extraction with dichloromethane, and the obtained organic layer was dried over anhydrous magnesium sulfate. The solvent was distilled off under reduced pressure, and the residue was then subjected to silica gel column chromatography to obtain the compound of interest as a colorless liquid (30 mg, 26%). 1H-NMR (400 MHz, CDCl3) delta: 0.89 (6H, t, J = 6.6 Hz), 1.21 – 1.42 (34H, m), 1.47 – 1.64 (6H, m), 1.71 (2H, tt, J = 6.6, 7.4 Hz), 1.99 – 2.09 (8H, m), 2.21 (6H, s), 2.27 (2H, t, J = 7.4 Hz), 2.77 (4H, t, J = 6.6 Hz), 4.14 (2H, t, J = 6.6 Hz), 4.63 – 4.72 (1H, m), 5.28 – 5.43 (8H, m). MS (ESI+) m/z 644 [M+H]+ HRMS (ESI+) m/z 644.6008 (2.6 mDa).
Statistics shows that 13330-96-6 is playing an increasingly important role. we look forward to future research findings about 4-(Dimethylamino)butan-1-ol.
Reference:
Patent; Daiichi Sankyo Company, Limited; KOIZUMI, Makoto; ONISHI, Yoshiyuki; NIWA, Takako; TAMURA, Masakazu; KASUYA, Yuji; (152 pag.)EP3020701; (2016); A1;,
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