With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.14002-80-3, name is Methyl 3-hydroxy-2,2-dimethylpropanoate, molecular formula is C6H12O3, molecular weight is 132.16, as common compound, the synthetic route is as follows.HPLC of Formula: C6H12O3
Example 2S nthesis of 2 , 2-dimethyl-3- (nitrooxy) propanoic acid HNO3 (2.4 mL, 54 mmol) was dissolved in AC2O (7.5 mL, 80 mmol) , cooled to 0C, and methyl 3-hydroxy-2 , 2-dimethylpropanoate (4 mL, 31 mmol) was added. The mixture was stirred for 1 hour, then poured into iced aHC03 (5%) and diluted with EtOAc. The organic phase was washed with brine, dried over Na2 S C>4 and concentrated affording methyl 2 , 2-dimethyl-3- (nitrooxy) propanoate as a clear oilThe residue was dissolved in NaOH (2.5 M, 20 mL) and MeOH (20 mL) and the solution was stirred at room temperature for 6 hours, and then acidified with HC1 (5%) to pH 3-4. The aqueous phase was extracted with EtOAc and the combined organic phases were washed with brine, dried over Na2 S C>4 and concentrated affording the title compound as a pale yellow solid (5.00 g, 98%)1H-NMR (CDCI3) : 4.53 (2H,s); 1.34 (6H,s).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,14002-80-3, Methyl 3-hydroxy-2,2-dimethylpropanoate, and friends who are interested can also refer to it.
Reference:
Patent; NICOX S.A.; ALMIRANTE, Nicoletta; IMPAGNATIELLO, Francesco; NICOTRA, Alessia; MANDELLI, Valentino; BRAMBILLA, stefania; WO2011/101245; (2011); A1;,
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