Reference of 431-38-9, Adding some certain compound to certain chemical reactions, such as: 431-38-9, name is 3-Amino-1,1,1-trifluoropropan-2-ol,molecular formula is C3H6F3NO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 431-38-9.
To a solution of intermediate Int-13 (1.0 equiv.) and racemic-3-amino-l,l,l-trifluoropropan-2-ol (3.0 equiv.) in 3: 1 dioxane/water (1.3 mL) was added triethylamine (5.0 equiv.). The reaction mixture was stirred at 90C for 18 h. After cooling to room temperature, the reaction mixture was reduced to half its volume, diluted with 1N aqueous HC1 solution and ethyl acetate. The layers were separated and the organic layer was washed successively with water then saturated aqueous sodium chloride solution, dried (sodium sulfate), and concentrated in vacuo to afford a crude solid. The crude material was purified by reverse phase HPLC using a gradient of 30 to 60% acetonitrile in water (modified by 0.1% formic acid) to provide racemic Compound 1-8 (34.5 mg, 55 % yield) as a pale yellow solid. 1H NMR (500 MHz, CD3OD) d (ppm): 9.35 (s, 1 H), 8.32 (s, 1 H), 8.12 (s, 1 H), 7.80 (s, 1 H), 7.25 – 7.30 (m, 1 H), 7.17 – 7.24 (m, 1 H), 6.99 – 7.02 (m, 1 H), 7.02 – 7.07 (m, 1 H), 4.66 (s, 2 H), 4.33 – 4.41 (m, 1 H), 4.03 (dd, 1 H), 3.76 (dd, 1 H). MS ES+ m/z = 467.2
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 431-38-9, 3-Amino-1,1,1-trifluoropropan-2-ol, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; CYCLERION THERAPEUTICS, INC.; RENNIE, Glen, Robert; RENHOWE, Paul, Allan; NAKAI, Takashi; MERMERIAN, Ara; CUMBERBATCH, Helen; (99 pag.)WO2019/126354; (2019); A1;,
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