With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.637031-88-0, name is 3,3-Difluorocyclobutanol, molecular formula is C4H6F2O, molecular weight is 108.09, as common compound, the synthetic route is as follows.SDS of cas: 637031-88-0
A solution of (racemic)-2′,3′,4′-trifluoro-7′-(fluoromethylsulfonyl)spiro[l,3-dioxolane-2, -indane] (13.5 mg, 0.041 mmol) and 3,3-difluoro-cyclobutanol (6.5 mu^, 0.066 mmol) in acetonitrile (1.0 mL) at 25 C was treated with potassium hydroxide (3.5 mg, 0.0600mmol) and stirred at 25 C for 1 h. Volatiles were removed by concentration under reduced pressure. The reaction mixture was poured into 20 mL of water and extracted with 3 x 20 mL EtOAc. The combined organics were rinsed with 10 mL of brine, dried with MgS04, filtered, and concentrated to dryness. The product was used without further purification. ESI (+) [M+ H4]+ m/z 432.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,637031-88-0, 3,3-Difluorocyclobutanol, and friends who are interested can also refer to it.
Reference:
Patent; PELOTON THERAPEUTICS, INC.; DIXON, Darryl, David; GRINA, Jonas; JOSEY, John, A.; RIZZI, James, P.; SCHLACHTER, Stephen, T.; WALLACE, Eli, M.; WANG, Bin; WEHN, Paul; XU, Rui; YANG, Hanbiao; (237 pag.)WO2016/144825; (2016); A1;,
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