As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 6642-34-8, name is (6-Bromobenzo[d][1,3]dioxol-5-yl)methanol, molecular formula is C8H7BrO3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Safety of (6-Bromobenzo[d][1,3]dioxol-5-yl)methanol
General procedure: In an oven dried round bottomed flask fitted with a rubber septum, were added alcohol 1 (100 mg, 0.30-0.46 mmol), NaH (1.20-1.84 mmol) and DMF (3 mL) followed by addition of allylbromide (0.60-0.92 mmol) at room temperature under a nitrogen atmosphere. The suspension was allowed to stir at the same temperature for 1 h. Progress of the allylation was monitored by TLC till the reaction is completed.GP-3was followed to the alcohol 1f (100 mg, 0.43 mmol) with allyl bromide (104.8 mg, 0.86 mmol) and NaH (42 mg, 1.73 mmol) in DMF (3 mL) at room temperature under a nitrogen atmosphere. Then, the reaction mixture was stirred at the same temperature for 1 h.
With the rapid development of chemical substances, we look forward to future research findings about 6642-34-8.
Reference:
Article; Gopi Krishna Reddy; Krishna; Satyanarayana; Tetrahedron Letters; vol. 53; 42; (2012); p. 5635 – 5640;,
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