Synthetic Route of 431-38-9, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.431-38-9, name is 3-Amino-1,1,1-trifluoropropan-2-ol, molecular formula is C3H6F3NO, molecular weight is 129.0811, as common compound, the synthetic route is as follows.
A solution of 150 mg intermediate 33, 107 mg 3-amino-1 ,1 ,1 -trifluoropropan-2-ol, 317 mg HATU, 2.5 mg 4-dimethylaminopyridine and 0.22 mL ethyldiisopropylamine in 3.1 mL of DMF was stirred at room temperature for 14 hours. Then the reaction was filtered and the solution was subjected to RP-HPLC ((column: X-Bridge C18 5muetaiota 100x30mm, mobile phase: acetonitrile / water (0.2 Vol% ammonia 32%)-gradient)) to yield 1 14 mg 6-[4- (difluoromethyl)phenyl]-2-(3-fluorophenyl)-3-oxo-/V-(3,3,3-trifluoro-2-hydroxypdihydropyridazine-4-carboxamide. 1H-NMR (400 MHz, DMSO-d6): delta = 3.43-3.52 (m, 1 H); 3.72-3.80 (m, 1 H); 4.19-4.27 (m, 1 H); 6.67 (s, 1 H); 7.13 (t, 1 H); 7.40 (ddt, 1 H); 7.54-7.67 (m, 3H); 7.72 (d, 2H); 8.12 (d, 2H); 8.71 (s, 1 H); 9.64 (t, 1 Eta).
Statistics shows that 431-38-9 is playing an increasingly important role. we look forward to future research findings about 3-Amino-1,1,1-trifluoropropan-2-ol.
Reference:
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; DEUTSCHES KREBSFORSCHUNGSZENTRUM (DKFZ); SCHMEES, Norbert; GUTCHER, Ilona; IRLBACHER, Horst; BADER, Benjamin; ZHAO, Na; PLATTEN, Michael; (437 pag.)WO2017/202816; (2017); A1;,
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