Application of 4704-94-3, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 4704-94-3, name is 2-(Hydroxymethyl)propane-1,3-diol. This compound has unique chemical properties. The synthetic route is as follows.
Production Example 10-15-Hydroxymethyl-1,3-dioxane To a dichloromethane (4.9 mL) suspension of 2-hydroxymethyl-1,3-propanediol (1.00 g, 9.41 mmol), were added formaldehyde dimethyl acetal (2.94 mL, 33.3 mmol), lithium bromide (159 mg, 1.84 mmol) and p-toluenesulfonic acid monohydrate (160 mg, 0.843 mmol), and the mixture was stirred at room temperature for three days. To the mixture, was added triethylamine (1.0 mL), the solvent was distilled off under reduced pressure, and the residue was purified by silica gel column chromatography to obtain the title compound (380 mg, 3.22 mmol) from fraction of n-heptane:ethyl acetate (4:1).1H-NMR (400 MHz, CDCl3) delta: 1.55 (br.s, 1H), 1.92-2.00 (m, 1H), 3.75 (dd, J=4.8, 6.8 Hz, 2H), 3.79 (dd, J=6.0, 11.6 Hz, 2H), 4.01 (dd, J=4.0, 11.6 Hz, 2H), 4.80 (d, J=6.4 Hz, 1H), 4.86 (d, J=6.4 Hz, 1H).
According to the analysis of related databases, 4704-94-3, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Eisai R&D Management Co., Ltd.; US2011/86882; (2011); A1;,
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