Synthetic Route of 20712-12-3, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 20712-12-3, name is (2-Amino-5-bromophenyl)methanol. A new synthetic method of this compound is introduced below.
A mixture of (2-amino-5-bromophenyl)methanol (10 g, 49.5 mmol) and MnO2 (25.8 g, 296.6 mmol) in CH2Cl2 (400 mL) was stirred at RT overnight. LCMS showed the reaction was completed. The solid was filtered off, and the filtrate was concentrated to give the title compound as a light yellow solid (8 g, 81percent), which was directly used in next step without further purification. MS (ES+) C7H6BrNO requires: 199, found: 200, 202 [M+H]+.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,20712-12-3, (2-Amino-5-bromophenyl)methanol, and friends who are interested can also refer to it.
Reference:
Patent; BLUEPRINT MEDICINES CORPORATION; Bifulco, JR., Neil; DiPietro, Lucian V.; Miduturu, Chandrasekhar V.; US2015/197519; (2015); A1;,
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