Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1205037-95-1, name is trans-3-Aminocyclobutanol hydrochloride. This compound has unique chemical properties. The synthetic route is as follows. Quality Control of trans-3-Aminocyclobutanol hydrochloride
In an ice bath, 44.5 mg (1 .12 mmol) sodium hydride (60% dispersion in mineral oil) were dispensed in 5 mL of anhydrous THF. 91 .6 mg (0.742 mmol) trans-3- aminocyclobutan-1 -ol (hydrochloride salt) were slowly added. Stirring at 0 C was continued for 15 min. 100 mg (0.371 mmol) of intermediate 2 were added, the ice bath was removed and the resulting mixture was stirred for 5 days at 40 C. The reaction mixture was carefully poured into water. The aqueous layer was extracted with ethyl acetate. The combined organic layers were dried over magnesium sulfate, and concentrated. The crude product was purified by HPLC to give 32 mg of the title compound as a solid material. 1H-NMR (300 MHz ,DMSO-d6), delta [ppm]= 2.49-2.57 (2H), 3.72 (2H), 5.53 (1 H), 7.01 (1 H), 7.31 (2H), 7.58-7.67 (2H), 7.71 -7.77 (1 H), 8.1 1 -8.19 (2H). LC-MS (Method 3): Rt = 0.73 min; MS (ESIpos) m/z = 321 [M+H]+.
If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 1205037-95-1, trans-3-Aminocyclobutanol hydrochloride.
Reference:
Patent; Bayer Intellectual Property GmbH; EIS, Knut; PUeHLER, Florian; ZORN, Ludwig; SCHOLZ, Arne; LIENAU, Philip; GNOTH, Mark, Jean; BOeMER, Ulf; GUeNTHER, Judith; HITCHCOCK, Marion; WO2013/34570; (2013); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts