Related Products of 612-16-8, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.612-16-8, name is (2-Methoxyphenyl)methanol, molecular formula is C8H10O2, molecular weight is 138.16, as common compound, the synthetic route is as follows.
Add 2-methylquinoline (1mmol), 2-methoxybenzyl alcohol (2.5mmol), TEMPO (0.1mmol), Fe (NO3) 3.9H2O (0.1mmol) andt-BuOK (2mmol) was sequentially added to a flask containing 2mL of THF,The air in the flask was replaced with oxygen, and the reaction was stirred at 50 C.The reaction process was monitored by thin layer chromatography. After the reaction was completed, it was quenched with water (10 mL).The reaction product was extracted with ethyl acetate (3 × 20 mL), washed with saturated brine (20 mL), dried over anhydrous Na2SO4, filtered, and the resulting filtrate was concentrated, and passed through silica gel column chromatography (200-300 mesh, the developing solvent was petroleum ether). (20: 1 mixed solution with ethyl acetate in volume ratio) yielded 215.0 mg of product with a yield of 82%.
Statistics shows that 612-16-8 is playing an increasingly important role. we look forward to future research findings about (2-Methoxyphenyl)methanol.
Reference:
Patent; Hebei University of Science and Technology; Zhang Zhiguang; Zhang Yong; Li Ling; Dai Siwei; Li Xingxi; (18 pag.)CN110804015; (2020); A;,
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