With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.623-04-1, name is (4-Aminophenyl)methanol, molecular formula is C7H9NO, molecular weight is 123.1525, as common compound, the synthetic route is as follows.Application In Synthesis of (4-Aminophenyl)methanol
portion of HBTU (1.6 g, 4.3 mmol) was added to a solution of Fmoc-Leu(OH) (1 g, 2.8 mmol) dissolved in 5 mL of 4% NMM in DMF and was left to stir under N2 for10 min. A portion of p-aminobenzyl alcohol (357 mg, 2.89 mmol) was then added to the reactionmixture under N2. After stirring for 5 h the reaction mixture was added to 50 mL of DCM andwashed 3 times with 50 mL of 10% LiCl in water. The organic layer was dried over sodiumsulphate and evaporated to dryness under vacuum. Flash silica-gel chromatography (3.5 %MeOH in CH2Cl2) afforded 1 as a white solid (954 mg, 69%).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,623-04-1, (4-Aminophenyl)methanol, and friends who are interested can also refer to it.
Reference:
Article; Bakthavatsalam, Subha; Franz, Katherine J.; George, Daniel J.; Wiangnak, Petpailin; Zhang, Tian; Bioorganic and medicinal chemistry letters; (2020);,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts