Synthetic Route of 349-75-7, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.349-75-7, name is (3-(Trifluoromethyl)phenyl)methanol, molecular formula is C8H7F3O, molecular weight is 176.14, as common compound, the synthetic route is as follows.
3-Trifluoromethylbenzyl alcohol (10 g, 56.8 mmol)And pyridine (6.74 g, 85.2 mmol)Was dissolved in 50 ml of DCM at -10 C,The triphosgene was dissolved in 50 ml of DCM,A solution of 3-trifluoromethylbenzyl alcohol and pyridine in DCM was added dropwise to a solution of triphosgene in DCM,The reaction was carried out at -10 C for 2 hours,Room temperature reaction for 42 hours,TLC monitoring,The reaction was terminated, the solvent was decompressed, extracted with EA,Washed three times with water,Combined organic layer,Concentrated in vacuo to give 12.7 g of a colorless oil,Yield 93.7%.
The chemical industry reduces the impact on the environment during synthesis 349-75-7, I believe this compound will play a more active role in future production and life.
Reference:
Patent; North Nationalities University; Hong Wei; Wang Hao; Yang Hao; Ouyang Yifan; Tan Xiaoli; Sun Yutong; Zhu Xuanli; Wang Zhe; (18 pag.)CN106749070; (2017); A;,
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