Synthetic Route of 769-30-2, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 769-30-2, name is Benzo[d][1,3]dioxol-4-ylmethanol. This compound has unique chemical properties. The synthetic route is as follows.
Example 6; Method AT5; Preparation of 1-Benzof1 3]dioxol-4-yl-2-bromo-ethanone; Step 1: Preparation of starting material 1-Benzor1, 3]dioxol-4-yl-ethanone; To a solution of MeMgBr in THF (1 M, 50 mL, 50 mmol, 1.5 eq) was diluted with 50 mL THF and cooled to-10 C. A solution of benzo [1,3] dioxole-4-carboxaldehyde (5.0 g, 33.3 mmol) in 50 mL THF was slowly added, and the reaction left to stir for 1 h. The reaction mixture was then quenched by pouring into 500 mL of ice cold sat. ammonium chloride and the mixture extracted with ether. The organic layers were dried over sodium sulfate and filtered through a plug of silica gel before concentrating in vacuo, providing 4.9 g of a white solid. A mixture of this solid (2.0 g, 12.0 mmol) and MnO2 (10.5 g, 120. 4 mmol, 10.0 eq) in 75 mL diethyl ether was stirred vigorously for 48 h. The reaction mixture was then filtered first through a plug of silica gel, then through a 0. 46 um frit before concentrating in vacuo to provide 2. 1g of an off-white solid. Purification by MPLC (Biotage) using a hexane-ethyl acetate gradient provided 1.47 g (74%) of 1- benzo [1,3] dioxol-4-yl-ethanone as an off-white solid. 1H-NMR (CDC13) 6 7.35 (d, J = 8 Hz, 1H), 6.97 (dm, J = 8 Hz, 1H), 6.87 (dd, J = 8 Hz, 1H), 6.08 (s, 2 H), 2.59 (s, 3H); TLC Rf = 0.18, 25% ethyl acetate-hexanes.
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 769-30-2, Benzo[d][1,3]dioxol-4-ylmethanol.
Reference:
Patent; BAYER PHARMACEUTICALS CORPORATION; WO2003/72561; (2003); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts