Related Products of 33893-85-5 , The common heterocyclic compound, 33893-85-5, name is 4-(Hydroxymethyl)cyclohexanol, molecular formula is C7H14O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
Example 42 Synthesis of Compound I-31 To a solution of 4-(hydroxymethyl)cyclohexan-1-ol (0.237 g, 1.82 mmol) in THF (15 mL) was added triphenylphosphine (0.718 g, 2.74 mmol) and 4,6-Dichloropyrimidin-5-ol (0.3 g, 1.82 mmol). To the mixture was added di-tert-butyl azodicarboxylate (0.63 g, 2.74 mmol) at 0 C., the mixture was stirred at room temperature for 18 hr. The reaction mixture was concentrated in vacuo. The residue was purified by column chromatography on silica gel (hexane:ethyl acetate=9:1 as eluent) to afford the 4-(((4,6-dichloropyrimidin-5-yl)oxy)methyl)cyclohexan-1-ol (0.15 g, 30% yield). LC/MS APCI: Calculated 276.04; Observed m/z [M+H)]+ 277.0.
The synthetic route of 33893-85-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Arrien Pharmaceuticals LLC; Vankayalapati, Hariprasad; US2020/131154; (2020); A1;,
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