Share a compound : (2,5-Dimethoxyphenyl)methanol

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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 33524-31-1, name is (2,5-Dimethoxyphenyl)methanol. A new synthetic method of this compound is introduced below., Product Details of 33524-31-1

Example 10; 5-Chloro-1-(2,5-dimethoxybenzyl)-1H-indole-2-carboxylic acid (3-hydroxy-2,2- dimethylpropyDamide EPO A solution of phosphorous tribromide (5.74ml, 60.4mmol) in anhydrous DCM (90ml) was added over 20min to a cooled, stirred solution of 2,5-dimethoxybenzyl alcohol (25.Og, 148.8mmol) in DCM (180ml), maintaining the temperature between -5C and 00C. Following the addition, the reaction was stirred at this temperature for a further 20 min. when water (200ml) was added. After separation of the layers, the organic was washed with water (3x200ml), dried with magnesium sulfate and evaporated to dryness under reduced pressure. The resulting crude product was crystallised from diethyl ether/heptane to afford 2-bromomethyl-1,4-dimethoxy-benzene (24.2g, 72%).The title compound was then prepared in a manner similar to that described in Example 1. 1H NMR (400MHz, CDCI3) deltaH : 0.88(s, 6H), 3.08(d, 2H, J=7.0), 3.25(d, 2H, J=6.8), 3.52(t, 1 H, J=7.0), 3.57(s, 3H), 3.84(s, 3H), 5.75(s, 2H), 6.03(d, 1H, J=2.9), 6.59(br t, 1H, J=6.8), 6.68(dd, 1 H, J=8.8, 2.9), 6.80(d, 1 H, J=8.8), 6.85 (s, 1H), 7.19(dd, J=8.8, 1.9), 7.27(m, 1H), 7.60(d, 1 H, J=1.9); EIMS: m/z = 431.3 [M+H]+.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 33524-31-1, (2,5-Dimethoxyphenyl)methanol.

Reference:
Patent; N.V. ORGANON; WO2006/100208; (2006); A1;,
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