Reference of 2425-28-7 , The common heterocyclic compound, 2425-28-7, name is 2-Bromo-1-phenylethan-1-ol, molecular formula is C8H9BrO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
General procedure: To a solution of the olefin (0.5-1.2mmol) in 10-16mL of acetonitrile-water (1:1) mixture was added NBS (1.05equiv) at rt. The reaction mixture was stirred until all the olefin was consumed, as monitored by TLC analysis. Subsequently, TetMe-IA (10mol%) and Oxone (1.0equiv) were introduced into the reaction mixture, and the stirring was continued. After completion of the oxidation as judged by TLC analysis, the reaction mixture was washed with saturated NaHCO3 solution. The organic matter was extracted 2-3 times with ethyl acetate or dichloromethane, and the combined organic extract was dried over anhyd Na2SO4. The solvent was removed in vacuo and the resultant residue was subjected to a short-pad silica gel column chromatography to isolate pure alpha-bromoketone.
The synthetic route of 2425-28-7 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Chandra, Ajeet; Parida, Keshaba Nanda; Moorthy, Jarugu Narasimha; Tetrahedron; vol. 73; 40; (2017); p. 5827 – 5832;,
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