In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 4442-79-9, name is 2-Cyclohexylethanol, the common compound, a new synthetic route is introduced below. Safety of 2-Cyclohexylethanol
General procedure: The N-substituted phthalimides were prepared according to literature.30 A mixture of phthalimide (2.21 g, 15 mmol), triphenylphosphine (3.93 g, 15 mmol), and appropriate alcohol (15 mmol) in 20 mL of dry THF was cooled to 0 C. Diethyl azodicarboxylate (DEAD) (2.61 g, 15 mmol) in 15 mL of dry THF was slowly added dropwise (1 h). The reaction mixture was then allowed to warm to room temperature and stirred overnight. Solvent was evaporated under reduced pressure and the residue suspended in Et2O. After the precipitate was filtered, the solvent was evaporated and the residue purified by column chromatography [eluent CH2Cl2] to afford appropriate N-substituted phthalimide.
The synthetic route of 4442-79-9 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Wicek, Ma?gorzata; Kottke, Tim; Ligneau, Xavier; Schunack, Walter; Seifert, Roland; Stark, Holger; Handzlik, Jadwiga; Kie?-Kononowicz, Katarzyna; Bioorganic and Medicinal Chemistry; vol. 19; 9; (2011); p. 2850 – 2858;,
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