With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.59854-12-5, name is tert-Butyl 4-hydroxybutanoate, molecular formula is C8H16O3, molecular weight is 160.2108, as common compound, the synthetic route is as follows.name: tert-Butyl 4-hydroxybutanoate
To a suspension of Boc-Pro-OH (9.7 g, 0.045 mol), 4-aminomethyl-N-methoxy-benzamidine (7.34 g, 0.041 mol; see step (ii) above) and dimethylaminopyridine (7.8 g, 0.064 mol) in 300 mL of acetonitrile was added EDC base (11.7 mL, 0.068 mol). The mixture was stirred for 18 h, concentrated and partitioned between water and EtOAc. The organic layer. was washed with water, aqueous sodium bicarbonate, dried (MgSO4) and evaporated. The crude product was flash chromatographed on silica gel with EtOAc. Yield: 9;73 g (63%).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,59854-12-5, tert-Butyl 4-hydroxybutanoate, and friends who are interested can also refer to it.
Reference:
Patent; Inghardt, Tord; Johansson, Anders; Svensson, Arne; US2004/19033; (2004); A1;,
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