Related Products of 127-66-2, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.127-66-2, name is 2-Phenylbut-3-yn-2-ol, molecular formula is C10H10O, molecular weight is 146.19, as common compound, the synthetic route is as follows.
(2-Ethoxybut-3-yn-2-yl)benzene (Table 2, entry 1) [39a]:2-phenyl-3-butyn-2-ol (0.106 g, 0.728 mmol) was added to a 5-mLscrew cap vial and dissolved in CH2Cl2(1 mL). Ethanol (0.036 g,0.897 mmol) was added followed by the addition of [Fc]PF6(0.007 g, 0.022 mmol). The vial was then sealed and heated at40C for 3 days. The solvent was removed and the residue waschromatographed on a neutral alumina oxide (Aluminar®) column(2.5 × 30 cm, hexane and then CH2Cl2) to give the product as a yel-low solid (0.085 g, 0.487 mmol, 67percent). NMR (, CDCl3)1H: 7.67?7.29(m, 7H, aromatic), 3.69 (doublet of quintets, 1 H,2JHH= 7.2 Hz,2JHH= 4.2 Hz, OCHH?), 3.22 (doublet of quintets, 1H,2JHH= 7.2 Hz,2JHH= 4.2 Hz, OCHH?), 2.74 (s, 1H, C CH), 1.78 (s, 3H, CH3), 1.24 (t,3H,2JHH= 7.2 Hz, OCH2CH3) ppm.13C{1H}: 143.3 (s, aromatic ipso),128.6 (s, aromatic), 128.5 (s, aromatic), 127.9 (s, aromatic), 127.6(s, aromatic*), 126.1 (s, aromatic), 84.7 (s, C CH), 75.9 (s, CC CH),75.2 (s, C CH), 60.6 (s, OCH2), 33.2 (s, CH3), 15.6 (s, OCH2CH3)ppm. IR (ATR, Neat): 3284 (m), 3055 (w), 2973 (m), 2926(w), 1714(s), 1670 (s), 1575 (s), 1491 (s), 1335 (s), 1264 (s), 1057 (s), 997 (s)
The chemical industry reduces the impact on the environment during synthesis 127-66-2, I believe this compound will play a more active role in future production and life.
Reference:
Article; Queensen, Matthew J.; Rabus, Jordan M.; Bauer, Eike B.; Journal of Molecular Catalysis A: Chemical; vol. 407; (2015); p. 221 – 229;,
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