Synthetic Route of 52059-53-7, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.52059-53-7, name is 2-(3-Fluorophenyl)ethanol, molecular formula is C8H9FO, molecular weight is 140.1549, as common compound, the synthetic route is as follows.
General procedure: To a solution of 2-(4-fluorophenyl)ethan-1-ol (1.12g, 7.99mmol) in DCM (45mL) at 0C was added imidazole (0.60g, 8.8mmol), triphenylphosphine (2.31g, 8.80mmol), and iodine (2.03g, 8.00mmol) in rapid succession. The mixture was allowed to stir at 0C for 10min before being gradually warmed to room temperature and let stir an additional 3h. Once TLC confirmed complete conversion the reaction was quenched with saturated aqueous Na2S2O3 (90mL) and the resulting solution extracted with DCM (3×30mL). The resulting organics were dried over MgSO4 and concentrated in vacuo. The resulting white solid was resuspended in 100mL hexanes and filtered to remove the byproduct triphenylphosphine oxide as a white precipitate. Following filtration the crude material was purified using Teledyne ISCO Combi Flash system (40g column, solid loading on silica, 100% hexanes, 20min run) to afford 1-fluoro-4-(2-iodoethyl)benzene (1.43g, 72%) as a clear oil.
The chemical industry reduces the impact on the environment during synthesis 52059-53-7, I believe this compound will play a more active role in future production and life.
Reference:
Article; Jeffries, Daniel E.; Witt, Jonathan O.; McCollum, Andrea L.; Temple, Kayla J.; Hurtado, Miguel A.; Harp, Joel M.; Blobaum, Anna L.; Lindsley, Craig W.; Hopkins, Corey R.; Bioorganic and Medicinal Chemistry Letters; vol. 26; 23; (2016); p. 5757 – 5764;,
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