Electric Literature of 770-71-8 , The common heterocyclic compound, 770-71-8, name is Adamantan-1-ylmethanol, molecular formula is C11H18O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
The adamantane 4-methylbenzenesulfonate was synthesized by reacting adamantyl alcohol (20.5 g, 123 mmol) with p-toluenesulfonic chloride (23.6 g, 123 mmol) in 75 mL of regular DCM, in the presence of 25 mL of triethylamine for 48 hours at room temperature. More DCM was added (100 mL) and the organic layer was washed with water (3×100 mL). Drying, (MgSO4), and evaporation of the solvent gave 34.5 g of tea color oil which under trituration with hexane afforded white solid adamantane 4-methylbenzenesulfonate (30.5 g, 76%).
The synthetic route of 770-71-8 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; NITTO DENKO CORPORATION; RACHWAL, MILA; YAMAMOTO, MICHIHARU; (134 pag.)JP2016/509621; (2016); A;,
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