In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 4254-29-9, name is 2,3-Dihydro-1H-inden-2-ol, the common compound, a new synthetic route is introduced below. Formula: C9H10O
To a solution of 2,3-dihydro-1H-inden-2-ol 215A (1.6 g, 12 mmol) in CHCl3(40 mL) was added pyridine (0.24 mL) and PBr3(1.28 mL) at 0 C. The mixture was heated at reflux for 1 hour and stirred at room temperature overnight. The reaction mixture was poured into ice-water (50 mL) and extracted with dichloromethane (30 mL x 3). The combined organic layers was washed with brine (40 mL), dried over anhydrous sodium sulfate, filtered, and concentrated under reduced pressure. The residue was purified with column chromatography on silica gel (petroleum ether, 100% v/v) to furnish Compound 215B. LC-MS (ESI) m/z: non-ionizable compound under routine conditions used;1H-NMR (CDCl3, 400 MHz): delta (ppm) 3.32-3.37 (m, 2H), 3.49-3.55 (m, 2H), 4.74-4.79 (m, 1H), 7.20- 7.28 (m, 4H).
The synthetic route of 4254-29-9 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; BIOMARIN PHARMACEUTICAL INC.; WANG, Bing; (552 pag.)WO2017/214505; (2017); A1;,
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