Reference of 623-04-1, Adding some certain compound to certain chemical reactions, such as: 623-04-1, name is (4-Aminophenyl)methanol,molecular formula is C7H9NO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 623-04-1.
For Fmoc-Leu-PABA 2j, a solution of Fmoc-Leu-OH (353 mg, 1 mmol), EEDQ (495 mg, 2 mmol) and PABA (222 mg, 1.8 mmol) in DCM (10 ml) was stirred for 10 h. All volatiles were removed on a rotovap, the residue was dissolved in Et2O (40 ml), chilled on dry ice for 2h and the solid was separated by centrifugation. The obtained crude material was purified on a column, eluent gradient of MeOH (1-2%) in CHCl3. Yield 444 mg (97%). MS: 459.4 [M+1]+.
According to the analysis of related databases, 623-04-1, the application of this compound in the production field has become more and more popular.
Reference:
Patent; ARROWHEAD RESEARCH CORPORATION; CHENG, Weijun; WONG, So; ALMEIDA, Aaron, M.; ROZEMA, David, B.; BLOKHIN, Andrei, V.; CARLSON, Jeffrey, C.; WO2015/21092; (2015); A1;,
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