Reference of 100-86-7, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 100-86-7 as follows.
General procedure: To cooled (0 C) 95% sulfuric acid (10 ml) and undermagnetic stirring, was added dropwise a benzonitrile (1.25eq). Then (500 mg, 3.33mmol) of tertiary alcohol1,1-dimethyl-2-phenylethanol (1, commercial product) in cyclohexane (10 ml) was added to the solution. Afterreturn to room temperature, the resulting mixture was stirred under reflux for 2.5 hours. Then, the solution iscooled at room temperature and versed on ice-cold water under magnetic stirring. The solution is alkalizedwith ammonia. The organic layer was extracted with dichloromethane (100 ml), washed with a saturatedaqueous NaCl solution, dried over sodium sulfate and filtered. The solvent was removed in vacuo and thecrude material was then purified by chromatography (silicia gel) to afford the imine as pure compound.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,100-86-7, its application will become more common.
Reference:
Article; Selmi, Awatef; Aydi, Rihab; Mosset, Paul; Gree, Rene; Kammoun, Majed; Arkivoc; vol. 2019; 5; (2019); p. 108 – 120;,
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