As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1562-00-1, name is Sodium isethionate, molecular formula is C2H5NaO4S, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. SDS of cas: 1562-00-1
Approximately 1.7 g of Compound A was added to a bottle and dissolved in 34 mL of acetone, concentration of 50 mg/mL. 400 pL (20 mg of freebase) of the stock solution was then dispensed into 84 vials and the acetone allowed to evaporate. 1M stock solutions of each counterion were prepared in either THF, ethanol or water, where appropriate as outlined in Table 27. L-aspartic acid was added as neat counterion due to low solubility. 1.05 equivalents of each counterion was added at room temperature and observations made. 2-hydroxy ethanesulfonic acid was supplied as a sodium salt and had 1.05 equivalents of HC1 added after counterion addition. All samples were then temperature cycled using the following procedure: a) Heat to 40 C, hold for 1 hour; b) Cooled to room temperature, hold for 3 hours; c) Heat to 40 C, hold for 1 hour; and d) Samples were held at 5 C overnight.All samples displaying solutions had the lids removed from the vials and were allowed to evaporate at ambient temperature. Samples with solid material had the mother liquor removed and the solids analyzed by XRPD. The mother liquor was transferred to a new sample vial and stored at 5 C to allow for further precipitation. The analyzed solids on the XRPD plate were exposed to 40 C/75 % RH conditions for 6 hours before analysis by XRPD. Table 27. Solvents Used to make Acid Stock Solutions
With the rapid development of chemical substances, we look forward to future research findings about 1562-00-1.
Reference:
Patent; ALDEYRA THERAPEUTICS, INC.; MACHATHA, Stephen, Gitu; LOUGHREY, Jonathan, James; MCLACHLAN, Hannah, Ruth; SNEDDON, Gregor; (194 pag.)WO2020/33344; (2020); A1;,
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