Synthetic Route of 932-01-4 , The common heterocyclic compound, 932-01-4, name is 4,4-Dimethylcyclohexanol, molecular formula is C8H16O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
10399] Step 1: To a DCM (45 mE) solution of the 4,4- dimethylcyclohexanol (200 mg, 1.56 mmol) was added tnethylamine(4.9 mE, 35 mmol). The solution was cooled to 0 C. before methanesulfonyl chloride (0.324 mE, 2.34 mmol) was added dropwise. The resulting mixture was allowed to warm to RT over 13 h. The reaction was diluted with DCM and washed with water, the organic phase dried (Na2504), filtered and the filtrate concentrated in vacuo. No further purification was necessary to afford 4,4-dimethylcyclohexyl methanesulfonate.
The synthetic route of 932-01-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; NOVIRA THERAPEUTICS, INC.; Chen, Austin; Bravo, Yalda; Stock, Nicholas; Pedram, Bijan; Jacintho, Jason; Clark, Ryan C.; (76 pag.)US2016/151375; (2016); A1;,
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