Adding a certain compound to certain chemical reactions, such as: 100058-61-5, 3-(Benzyloxy)cyclobutanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 100058-61-5, blongs to alcohols-buliding-blocks compound. category: alcohols-buliding-blocks
To a solution of 3-benzyloxycyclobutanol (5.0 g, 28.0 mmol) in dichloromethane (40 mL)was added dropwise diethylaminosulfur trifluoride (7.41 mL, 56.1 mmol) at 0 C. Thereaction was stirred at 15 C for 16 h and quenched with ice water (50 mL). Saturated aqueous sodium bicarbonate was added (100 mL), and the mixture was extracted with dichloromethane (200 mL). The organic phase was washed with brine (100 mL), dried over sodium sulfate and concentrated. The crude product was purified by flash column chromatography (eluting gradient: 10% ethyl acetate in petroleum ether) to give (3- fluorocyclobutoxy)methylbenzene (1.30 g, 26%) as a yellow oil.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,100058-61-5, its application will become more common.
Reference:
Patent; F. HOFFMANN-LA ROCHE AG; GENENTECH, INC.; BRYAN, Marian C.; DO, Steven; DROBNICK, Joy; GOBBI, Alberto; KATSUMOTO, Tamiko; KIEFER, JR., James Richard; LIANG, Jun; RAJAPAKSA, Naomi S.; CHEN, Yongsheng; FU, Liqiang; LAI, Kwong Wah; LIU, Zhiguo; WAI, John; WANG, Fei; (322 pag.)WO2018/234345; (2018); A1;,
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