Reference of 4254-29-9, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.4254-29-9, name is 2,3-Dihydro-1H-inden-2-ol, molecular formula is C9H10O, molecular weight is 134.18, as common compound, the synthetic route is as follows.
General procedure: The alkylation was performed following a published procedure [29] with minor modifications. 1 (1.0 eq.) was dissolved in dry THF under nitrogen in oven-dried round-bottomed flask and alcohol (1.1-2.5 eq.) and PPh3 (1.1-2.5 eq.) was added. The nitrogen flow was temporarily removed when solid alcohols were added. When all of the PPh3 was dissolved, DIAD (1.0-2.5eq.), were added drop wise. The reaction was stirred at room temperature under nitrogen, until TLC indicated full consumption of the starting material, unless otherwise noted. The solvent was removed under reduced pressure and the crude product was purified by flash column chromatography or automated flash column chromatography.
The chemical industry reduces the impact on the environment during synthesis 4254-29-9, I believe this compound will play a more active role in future production and life.
Reference:
Article; Pettersson, Mariell; Bliman, David; Jacobsson, Jimmy; Nilsson, Jesper R.; Min, Jaeki; Iconaru, Luigi; Guy, R. Kiplin; Kriwacki, Richard W.; Andreasson, Joakim; Gr°tli, Morten; PLoS ONE; vol. 10; 5; (2015);,
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