Synthetic Route of 25392-41-0, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 25392-41-0, name is 4-(Chloromethyl)-7-hydroxy-2H-chromen-2-one. This compound has unique chemical properties. The synthetic route is as follows.
4-Chloromethylcoumarin 12c (2.1g, 10mmol) was dissolved in dry DMF (35mL) and then Cs2CO3 (3.9g, 12mmol) was added followed by 3-chlorobenzyl bromide (1.3mL, 10mmol) after 15min of stirring. The mixture was stirred at room temperature for 24h and then poured onto crushed ice. The resulting solid was filtered, washed several times with hot water and crystallized from CHCl3/n-hexane yielding the desired product. Yield: 87%. Spectroscopic and analytical data are in full agreement with those reported in the literature [39].
According to the analysis of related databases, 25392-41-0, the application of this compound in the production field has become more and more popular.
Reference:
Article; Pisani, Leonardo; Catto, Marco; Nicolotti, Orazio; Grossi, Giancarlo; Di Braccio, Mario; Soto-Otero, Ramon; Mendez-Alvarez, Estefania; Stefanachi, Angela; Gadaleta, Domenico; Carotti, Angelo; European Journal of Medicinal Chemistry; vol. 70; (2013); p. 723 – 739;,
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