Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 7589-27-7, name is 2-(4-Fluorophenyl)ethanol. A new synthetic method of this compound is introduced below., HPLC of Formula: C8H9FO
Example 1 Scheme A, step a: (R)-alpha-(2,3-Dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol (3) A suitable reactor maintained under nitrogen was charged with 4-fluorophenethyl alcohol (2.6 kg, 18.6 mol) and 18 L of methylene chloride. The stirred solution was cooled to and maintained at 0-5°C while triethylamine 2.85 kg (28.2 mol) was added fairly rapidly. The reaction temperature was maintained at 0-5 °C while adding methanesulfonyl chloride (2.5 kg, 21.8 mol) over 1 hour. The stirred reaction mixture was maintained at 0-5°C for 1 hour, then it was warmed to room temperature within approximately 2 hours. The reaction mixture was diluted with a solution of 0.5 kg of 33percent hydrochloric acid in 10 L of water. The organic phase was separated and washed with a solution of 0.2 kg of 33percent hydrochloric acid in 5 L of water. Both acidic extracts were combined and extracted with 5 L of methylene chloride. Both organic phases were combined, washed with 2 x 15 L of water, then dried with sodium sulfate (2 kg). Drying agent was filtered off and washed with 2 x 5 L of methylene chloride. The majority of the solvent was boiled off at atmospheric pressure, with the final amount distilled off at 35°C/500 torr to give 4-fluorophenethyl alcohol methanesulfonate (4.17 kg.)
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Reference:
Patent; Aventis Pharmaceuticals, Inc.; Hoechst Marion Roussel Deutschland GmbH; EP1734037; (2006); A2;,
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