Application of 4541-14-4 ,Some common heterocyclic compound, 4541-14-4, molecular formula is C11H16O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
A flame-dried round-bottom flask was charged with a solution of oxalylchloride (3.8 mL, 43.1 mmol) in CH2Cl2 (45 mL) at -78 C. The mixture was added to dimethylsulfoxide (6.1 mL, 87.1 mmol) at -78 C. This mixture was stirred for 20 min,and then a solution of the alcohol (5.0 g, 27.7 mmol), prepared as described inthe preceding procedure, in CH2Cl2 (14 mL) was added.After 20 min, triethylamine (19.3 mL, 138.5 mmol) was added to the reactionmixture and stirred for 10 min. The resulting mixture was warmed to roomtemperature and stirred for 1 h. The reaction mixture was diluted with ether(30 mL), and water (30 mL) was added. The organic layer was separated, and theaqueous layer was extracted with ether (2 × 30 mL), and washed with saturatedaqueous NaHCO3 (15 mL) and saturated aqueous NaCl (15 mL). Theorganic solutions were combined, dried (Na2SO4), and concentratedto afford the desired crude aldehyde (4.90 g, 27.5 mmol, 99%) as a colorlessoil which was used in the next step without further purification.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,4541-14-4, its application will become more common.
Reference:
Article; Lee, Jungmee; Oh, Hong-Se; Kang, Han-Young; Tetrahedron Letters; vol. 56; 9; (2015); p. 1099 – 1102;,
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