In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1004-24-6, name is (4-Methylenecyclohexyl)methanol, the common compound, a new synthetic route is introduced below. Formula: C8H14O
To a solution of (4-methylenecyclohexyl)methanol (1.1 g, 8.72 mmol) in acetonitrile (40 mL) was added a mixture of iodine (3.32 g, 13.07 mmol) in acetonitrile (120 mL) at 0 C. The reaction mixture was stirred at 0 C for 3 h. The reaction mixture was diluted with EtOAc and washed with aq. solution of Na2S203, IN NaOH, brine, dried (MgS04) and purified on a 40 g silica gel cartridge(EtOAc/hexane: 0 to 20%) to afford the product (0.53g, 24%). 1H NMR (400MHz, CHLOROFORM-d) ppm 3.94 (s, 2H), 3.14 (s, 2H), 2.01 – 1.93 (m, 2H), 1.90 – 1.80 (m, 2H), 1.75 – 1.66 (m, 5H).
The synthetic route of 1004-24-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; HEWAWASAM, Piyasena; LOPEZ, Omar D.; TU, Yong; WANG, Alan Xiangdong; XU, Ningning; KADOW, John F.; MEANWELL, Nicholas A.; GUPTA, Samayamunthula Venkata Satya Arun Kumar; KUMAR, Indasi J. Gopi; PUNUGUPATI, Suresh Kumar; BELEMA, Makonen; WO2015/5901; (2015); A1;,
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