Synthetic Route of 4277-34-3, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 4277-34-3 as follows.
General procedure: A ?10 g? Biotage SNAP cartridge wrapped in aluminum foil was used to house the modified silica gel (13.2 g). The (Z)-cyclooctene derivative (0.012-0.024 M in solvent) and methyl benzoate (2.0 equiv) were dissolved in the indicated solvent in a quartz flask. After sparging the contents with N2 for 15 minutes, the flask was placed in a Rayonet reactor and connected via PTFE tubing to a column (Biotage SNAP) and an FMI pump. The column was then packed with silver nitrate exchanged sulfonated silica gel. Any remaining space between the silica and the cartridge cap was filled with cotton. The column was flushed with the reaction solvent, followed by equilibration via circulation with the FMI pump (ca. 100 mL per minute). The solution in the quartz flask was then irradiated at 254 nm under continuous flow for the indicated time. The SNAP cartridge was washed with additional solvent, and then dried with a stream of compressed air. A solution of NH3-saturated MeOH was allowed to pass through the column and the effluent was collected until no more trans-cyclooctene product was detected by TLC. The collected solution was then concentrated by rotary evaporation and the residue was purified by flash silica gel chromatography to obtain pure trans-cyclooctenes.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,4277-34-3, its application will become more common.
Reference:
Article; Darko, Ampofo; Boyd, Samantha J.; Fox, Joseph M.; Synthesis; vol. 50; 24; (2018); p. 4875 – 4882;,
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